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研究與開發

RESEARCH AND DEVELOPMENT

熱烈祝賀華奧泰在國際學術期刊發表重要論文-HB0025

2021-12-02 247


熱烈祝賀華奧泰生物在國際學術期刊Frontiers in Immunology發表了題為 “A Novel Bispecific Antibody Targeting PD-L1 and VEGF with Combined Anti-Tumor Activities”的學術論文,華奧泰CEO朱向陽博士是該論文的通訊作者。

該論文充分論述了華奧泰自主研發的全球首個靶向PD-L1/VEGF的雙特異性融合蛋白HB0025卓越的CMC性能,顯著的體內體外協同抗腫瘤活性和巨大的臨床潛力。此研究為HB0025的臨床開發提供了扎實的理論支持。HB0025已被中美兩國監管機構批準進入臨床,目前正在開展一項評估HB0025安全性、耐受性和初步療效的國際多中心臨床研究。

論文下載鏈接:https://doi.org/10.3389/fimmu.2021.778978

(A) HB0025 treatment compared with HB0023, HB002.1T, and HB0023+HB002.1T in NCG mice. (B) HB0025 treatment compared with bevacizumab, atezolizumab, and bevacizumab+atezolizumab in NCG mice. *p < 0.05, **p < 0.01, ***p < 0.001 compared with HB0025 6mg/kg.


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